The Cognitive Neuroscience Laboratory (CNL) is a multidisciplinary research laboratory that studies the neural underpinnings of human behavior primarily using magnetic resonance imaging (MRI). Our two focus areas are cognition in the setting of sleep deprivation, and the cognitive neuroscience of aging. In addition to our own research, we support a number of other investigators.
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On this World Sleep Day (14 March '14), Prof Michael Chee comments on 'why getting enough sleep matters'.
Talking About The Walk With Singaporean Clinician Scientists
In this series, we follow the career journeys of Dr Michael Chee, Dr Ong Sin Tiong,
Dr Tai E-Shyong, and Dr Ooi Eng Eong.
Articles in Press
The .pdfs will be available shortly.
1. Yeo TBT, Krienen FM, Chee MWL. Estimates of segregation and overlap of functional connectivity networks in the human cerebral cortex. NeuroImage. 2013 (In press).
1 April 2014
To investigate the effects of post-learning sleep and sleep architecture on false memory in healthy older adults. A false memory was induced using the Deese-Roediger-McDermott (DRM) paradigm and assessed following nocturnal sleep and following a period of daytime wakefulness. Post-learning sleep structure was evaluated using polysomnography (PSG). [Download Article]
8 March 2014
Previous research suggests that sleep deprivation may heighten normal reactions to an aversive social encounter. In this study, we explored how 24 h of sleep deprivation may influence responses to ostracism. Ninety-six healthy young adults were randomly allocated to either the sleep-deprivation or well-rested condition, wherein they engaged in two rounds of a ball-tossing game (Cyberball) programmed so that they would be included or ostracized. [Download Article]
25 January 2014
Object recognition becomes impaired at faster presentation rates and here we show the neuroanatomical foci of where this might be exacerbated by sleep deprivation (SD). Twenty healthy human participants were asked to detect a target house in serially presented house pictures that appeared at 1–15 images/s. Temporal response profiles relating fMRI signal magnitude to presentation frequency were derived from task-responsive regions. [Download Article]
1 December 2013
Eyelid closures in fatigued individuals signify task disengagement in attention-demanding visual tasks. Here, we studied how varying degrees of eyelid closure predict responses to auditory stimuli depending on whether a participant is well rested or sleep deprived. We also examined time-on-task effects and how more and less vulnerable individuals differed in frequency of eye closures and lapses. [Download Article]
15 November 2013
Both sleep deprivation and extended task engagement (time-on-task) have been shown to degrade performance in tasks evaluating sustained attention. Here we used pulsed arterial spin labeling (pASL) to study participants engaged in a demanding selective attention task. The participants were imaged twice, once after a normal night of sleep and once after approximately 24 h of total sleep deprivation. We compared task-related changes in BOLD signal alongside ASL-based cerebral blood flow (CBF) changes. [Download Article]
1 November 2013
Patients with schizophrenia exhibit impairments in working memory that often appear in attenuated form in persons at high risk for the illness. The authors hypothesized that deviations in task-related brain activation and deactivation would occur in persons with an at-risk mental state performing a working memory task that entailed the maintenance and manipulation of letters. [Download Article]
1 June 2013
To determine whether sleep deprivation would affect the discounting of delayed rewards, of rewards entailing the expense of effort, or both. We measured rates of two types of reward discounting under conditions of rested wakefulness (RW) and sleep deprivation (SD). [Download Article]
Visual short-term memory (VSTM) is an important measure of information processing capacity and supports many higher-order cognitive processes. We examined how sleep deprivation (SD) and maintenance duration interact to influence the number and precision of items in VSTM using an experimental design that limits the contribution of lapses at encoding. [Download Article]