The Cognitive Neuroscience Laboratory (CNL) is a multidisciplinary research laboratory that studies the neural underpinnings of human behavior primarily using magnetic resonance imaging (MRI). Our two focus areas are cognition in the setting of sleep deprivation, and the cognitive neuroscience of aging. In addition to our own research, we support a number of other investigators.

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Perils of sleep deprivation

Professor Chee is featured in the recent issue of International Innovation, The Enigma. Download full article here.


Upcoming study

Last year, our lab embarked on a 2-week experimental sleep study looking at the effects of sleep restriction and extension on cognition in adolescents. This year, we look into ways to tackle chronic short sleep.

If you are between the ages of 15-19, and interested to participate, do keep the first 2-weeks of your December (2015) school holidays free! Watch this space for more details as recruitment will begin soon. :)


CNL at the 6th World Congress on Sleep Medicine (WASM 2015)

Professor Chee presented
Functional Imaging of Sleep Loss
at the symposium


Dr Lo gave an oral presentation on
Associations between Self-Resported
Sleep Duration and Cognitive Performance in Older Adults: A Systematic Review
and Meta-Analysis
Ms Leong presented a poster titled
Self-Reported Sleep Duration and Levels of Inflammatory Markers: Similarities and Differences across Genders


Functional Imaging of Sleep Loss
At the 6th World Congress on Sleep Medicine (WASM 2015) held in Seoul, Korea, Professor Chee reviews functional imaging research to date to understand what and why cognitive domains are impaired by sleep loss.

Slides to his talk can be found here.


Sleepless in Singapore
What is the lack of sleep costing us in terms of our work and our health? In this session, Professor Chee shares his expertise in sleep and cognition.

Click here to read more.


Aged to Perfection
Professor Chee gives us some tips on how we can stay sharp as we age.

Click here to read more.


Train Your Brain
We partner with Channel News Asia again - this time on the neural processes of aging.

Click here to read more.



1 May 2015


Recent studies demonstrate that baseline PVT performance carries information about vulnerability to subsequent sleep deprivation. But it remains unclear whether features of rested PVT performance can be used to classify a person’s relative performance in the sleep deprived state. In this study, we identified measures derived from baseline psychomotor vigilance task performance that can reliably predict vulnerability to sleep deprivation. [Download Article]

17 February 2015


Significant inter-individual differences in vigilance decline following sleep deprivation exist. We characterized functional connectivity in 68 healthy young adult participants in rested wakefulness and following a night of total sleep deprivation. [Download Article]

1 January 2015


Pathogenic effects of stress show interindividual variation and may be influenced by situational variables such as sleep loss. Here, we probed how the sympathetic nervous system might contribute to altered reactivity in sleep deprived persons. [Download Article]

25 October 2014


Voluntary sleep loss arising from lifestyle choices is prevalent despite it producing an unpleasant mental fog, fatigue and sleepiness that elevate the likelihood of accidents, cognitive errors and emotional dysregulation. Here, Professor Chee discusses the neural mechanisms underlying behavioral changes in the sleep-deprived state, more specifically on aspects of attention and visual processing. [Download Article]

23 September 2014


The association cortex supports cognitive functions enabling flexible behavior. Here, we explored the organization of human association cortex by mathematically formalizing the notion that a behavioral task engages multiple cognitive components, which are in turn supported by multiple overlapping brain regions. [Download Article]


Click here for more publications







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