The Cognitive Neuroscience Laboratory (CNL) is a multidisciplinary research laboratory that studies the neural underpinnings of human behavior primarily using magnetic resonance imaging (MRI). Our two focus areas are cognition in the setting of sleep deprivation, and the cognitive neuroscience of aging. In addition to our own research, we support a number of other investigators.

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16 June 2016, TODAY - Note to my sleep self: Do something about it
We know that not having enough sleep has negative impacts on various aspects of life. But what can we do about it? Professor Chee shared a few tips to help us re-evaluate our ways of life. Read more here.

25-27 May 2016
CNL’ers at the 6th Society for Biological Decision Making Meeting at Paris

Stijn busy explaining his poster
Mike, Stijn and Amitai Shenhav at the SBDM social

The Straits Times, 29 March 2016 - another news article that features our findings from the ‘Need for Sleep’ study. One of the main findings from the study is that recovery sleep can’t fully fix some cognitive deficits. Click here to read more.

12-13 March 2016

Professor Chee and Dr Lo at the 1st Congress of Asian Society of Sleep Medicine (ASSM). In this meeting, the main theme of our work is sleep and adolescents.

29 February 2016

Findings from our study, ‘Need For Sleep’ is featured in Science Daily. If you think that studying all night will help you to perform better, think twice!
Click here to read the publication.

21 January 2016

We are honoured to host Professor Sonia Ancoli-Israel during her visit as a Distinguished Visiting Scholar at Duke-NUS. Visit our Links to view her slides.




1 April 2016


There is compelling evidence that sleep facilitates consolidation of declarative memory, resulting in better memory performance after sleep than after a comparable duration of wakefulness. External stimulation can enhance specific brain oscillations leading to the reorganisation of memory traces and communication between cortical networks – processes that underlie systems consolidation of memory. Here, we investigated whether acoustic stimulation synchronized to slow waves can enhance these sleep features and facilitate memory consolidation during an afternoon nap. [Download Article]

19 March 2016


While cross-sectional studies are pertinent to the construction of new hypotheses, longitudinal studies are equally or maybe even more important because it may not be appropriate to extrapolate cross- sectional findings to predict the effects of ageing. Here, we examined the longitudinal intra- and inter-network functional connectivity changes in a cohort of relatively healthy older adults. [Download Article]

1 March 2016


Some of the world’s most sleep deprived students live in East Asia where students excel in standardized academic tests. This might reinforce the notion that ‘mind over matter’ can overcome negative effects of chronic sleep restriction. We found that in adolescents, partial sleep deprivation of comparable duration and severity to that examined in studies on young healthy adults elicited equivalent or greater neurobehavioral deficits across several cognitive domains. [Download Article]

1 January 2016


Sleep is important for optimal cognitive functioning across the lifespan. Among older adults (≥55 years), self-reported short and long sleep durations have been repeatedly, albeit inconsistently, reported to elevate the risk for poor cognitive function. This meta-analytic review quantitatively summarizes the risk for poorer cognitive function among short and long sleepers in older adults. [Download Article]

1 September 2015


Temporal expectation enables us to focus limited processing resources, thereby optimizing perceptual and motor processing for critical upcoming events. We investigated the effects of total sleep deprivation (TSD) on temporal expectation by evaluating the foreperiod and sequential effects during a psychomotor vigilance task (PVT). We also examined how these two measures were modulated by vulnerability to TSD. [Download Article]

8 July 2015


Making decisions about rewards that involve delay or effort requires the integration of value and cost information. The computation of the integrated value of a reward with its associated cost in the brain (subjective value) is thought to be critical in guiding choice behavior. The primary aim of the present study was to explore the neural substrates underlying cognitive effort discounting during the period when decisions are made. [Download Article]


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