
The Cognitive Neuroscience Laboratory (CNL) is a multidisciplinary research laboratory that studies the neural underpinnings of human behavior primarily using magnetic resonance imaging (MRI). Our two focus areas are cognition in the setting of sleep deprivation, and the cognitive neuroscience of aging. In addition to our own research, we support a number of other investigators.
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In this video abstract, we talk about our latest findings, published in
The American Journal of Clinical Nutrition (2013); 97 (5): 919.
Articles in Press
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The .pdfs will be available shortly.
1. Ong JL, Asplund CL, Chee MWL. Now you hear me, now you don’t: Eyelid closures as an indicator of auditory task disengagement. Sleep. 2013 (In Press).
2. Yaakub SN, Dorairaj K, Poh JS, Asplund CL, Krishnan, R, Lee J, Keefe RS, Adcock A, Wood SJ, Chee MWL, Preserved working memory, altered brain activation in persons at-risk for psychosis. Am J Psychiatr. 2013 (In Press).
3. Libedinsky C, Massar SAA, Ling A, Chee W, Huettel SA, Chee MWL. Sleep deprivation alters effort discounting but not delay discounting of monetary rewards. Sleep. 2013 (In Press).
4. Wee N, Asplund CL, Chee MWL. Sleep deprivation accelerates delay-related loss of visual short-term memories without affecting precision. Sleep. 2013 (In Press).
5. Asplund CL, Chee MWL. Time-on-task and sleep deprivation effects are evidenced in overlapping brain areas. NeuroImage. 2013 (In Press).
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3 April 2013
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Dietary disinhibition is a behavioral trait associated with weight gain and obesity. Because food choices are made according to the relative value assigned to each option, examination of valuation signals through functional magnetic resonance imaging (fMRI) may elucidate the neural basis for the association between dietary disinhibition and weight gain. [Download Article]
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March 2013
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The rising cost of health care and the burden of chronic illness are perennial concerns. Remarkably, there exists a measure that around 30% of city dwellers can implement to reduce their risk of accidents, coronary artery disease, diabetes, cancer and all-cause mortality while improving their cognitive performance. Unlike costly supplements or diets, this measure incurs no financial expense and unlike exercise, requires no exertion. That measure is improving sleep duration and quality. [Download Article]
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1 February 2013
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Rapidly detecting target object categories when objects are embedded in naturalistic scenes is facilitated by preparatory baseline signal changes. However, it is unclear as to what information most strongly predicts perceptual speed in terms of the minimal exposure duration required for accurate detection. Using novel surface-based spatiotemporal pattern classification, we found that while category-specific biases resulting from merely providing a category name can be detected in multiple cortical areas, only biases in lateral occipital complex predicted perceptual speed. [Download Article]
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27 March 2012
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Sleep deprivation (SD) has been shown to affect selective attention but it is not known how two of its component processes: target enhancement and distractor suppression, are affected. To investigate, young volunteers either attended to houses or were obliged to ignore them (when attending to faces) while viewing superimposed face–house pictures. MR signal enhancement and suppression in the parahippocampal place area (PPA) were determined relative to a passive viewing control condition. [Download article]
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16 January 2012
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Sleep deprivation (SD) can alter extrinsic, task-related fMRI signal involved in attention, memory and executive function. However, its effects on intrinsic low-frequency connectivity within the Default Mode Network (DMN) and its related anti-correlated network (ACN) have not been well characterized. We investigated the effect of SD on functional connectivity within the DMN, and on DMN-ACN anti-correlation, both during the resting state and during performance of a visual attention task (VAT). [Download Article]
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24 October 2011
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Even a single night of total sleep deprivation (SD) can have dramatic effects on economic decision making. Here we tested the novel hypothesis that SD influences economic decisions by altering the valuation process. Using functional magnetic resonance imaging we identified value signals related to the anticipation and the experience of monetary and social rewards (attractive female faces). We then derived decision value signals that were predictive of each participant’s willingness to exchange money for brief views of attractive faces in an independent market task. [Download article]
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9 September 2011
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Sleep deprivation (SD) can give rise to faltering attention but the mechanics underlying this remain uncertain. Using a covert attention task that required attention to a peripheral target location, we compared the effects of attention and SD on baseline activity prior to visual stimulation as well as on stimulus-evoked activity. [Download article]
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Volunteers Needed!
We are seeking volunteer participation for this current research study:
Attention and Visual Processing in Sleep Deprivation
This study will take place over approximately 2 weeks, and volunteers will undergo 2 magnetic resonance imaging (MRI) scanning sessions, with one session being an overnight sleep deprivation session.
If you are between 21 to 35 of age, with no chronic illnesses and have regular sleeping patterns (at least 6.5 hours of sleep every night), please fill up the sleep questionnaire here to take part in our study.