The Cognitive Neuroscience Laboratory (CNL) is a multidisciplinary research laboratory that studies the neural underpinnings of human behavior primarily using magnetic resonance imaging (MRI). Our two focus areas are cognition in the setting of sleep deprivation, and the cognitive neuroscience of aging. In addition to our own research, we support a number of other investigators.
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Talking About The Walk With Singaporean Clinician Scientists
In this series, we follow the career journeys of Dr Michael Chee, Dr Ong Sin Tiong,
Dr Tai E-Shyong, and Dr Ooi Eng Eong.
Articles in Press
The .pdfs will be available shortly.
1. Yeo TBT, Krienen FM, Chee MWL. Estimates of segregation and overlap of functional connectivity networks in the human cerebral cortex. NeiroImage. 2013 (In press).
1 December 2013
Eyelid closures in fatigued individuals signify task disengagement in attention-demanding visual tasks. Here, we studied how varying degrees of eyelid closure predict responses to auditory stimuli depending on whether a participant is well rested or sleep deprived. We also examined time-on-task effects and how more and less vulnerable individuals differed in frequency of eye closures and lapses. [Download Article]
15 November 2013
Both sleep deprivation and extended task engagement (time-on-task) have been shown to degrade performance in tasks evaluating sustained attention. Here we used pulsed arterial spin labeling (pASL) to study participants engaged in a demanding selective attention task. The participants were imaged twice, once after a normal night of sleep and once after approximately 24 h of total sleep deprivation. We compared task-related changes in BOLD signal alongside ASL-based cerebral blood flow (CBF) changes. [Download Article]
1 November 2013
Patients with schizophrenia exhibit impairments in working memory that often appear in attenuated form in persons at high risk for the illness. The authors hypothesized that deviations in task-related brain activation and deactivation would occur in persons with an at-risk mental state performing a working memory task that entailed the maintenance and manipulation of letters. [Download Article]
1 June 2013
To determine whether sleep deprivation would affect the discounting of delayed rewards, of rewards entailing the expense of effort, or both. We measured rates of two types of reward discounting under conditions of rested wakefulness (RW) and sleep deprivation (SD). [Download Article]
Visual short-term memory (VSTM) is an important measure of information processing capacity and supports many higher-order cognitive processes. We examined how sleep deprivation (SD) and maintenance duration interact to influence the number and precision of items in VSTM using an experimental design that limits the contribution of lapses at encoding. [Download Article]
3 April 2013
Dietary disinhibition is a behavioral trait associated with weight gain and obesity. Because food choices are made according to the relative value assigned to each option, examination of valuation signals through functional magnetic resonance imaging (fMRI) may elucidate the neural basis for the association between dietary disinhibition and weight gain. [Download Article]
The rising cost of health care and the burden of chronic illness are perennial concerns. Remarkably, there exists a measure that around 30% of city dwellers can implement to reduce their risk of accidents, coronary artery disease, diabetes, cancer and all-cause mortality while improving their cognitive performance. Unlike costly supplements or diets, this measure incurs no financial expense and unlike exercise, requires no exertion. That measure is improving sleep duration and quality. [Download Article]
1 February 2013
Rapidly detecting target object categories when objects are embedded in naturalistic scenes is facilitated by preparatory baseline signal changes. However, it is unclear as to what information most strongly predicts perceptual speed in terms of the minimal exposure duration required for accurate detection. Using novel surface-based spatiotemporal pattern classification, we found that while category-specific biases resulting from merely providing a category name can be detected in multiple cortical areas, only biases in lateral occipital complex predicted perceptual speed. [Download Article]