The Cognitive Neuroscience Laboratory (CNL) is a multidisciplinary research laboratory that studies the neural underpinnings of human behavior primarily using magnetic resonance imaging (MRI). Our two focus areas are cognition in the setting of sleep deprivation, and the cognitive neuroscience of aging. In addition to our own research, we support a number of other investigators.
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5 February 2010
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Most prior studies on selective attention in the setting of total sleep deprivation (SD) have focused on behavior or activation within fronto-parietal cognitive control areas. Here, we evaluated the effects of SD on the top-down biasing of activation of ventral visual cortex and on functional connectivity between cognitive control and other brain regions. [Download article]
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8 December 2009
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Read the original ST article
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Read this article and concerned about MRI scans?
The recent article in The Straits Times, “Dangerous brain scans found” should prove little cause for alarm among Magnetic Resonance Imaging (MRI) participants. The dangerous brain scans in question refer to a series of Computed Tomography, or CT brain perfusion scans. The potential dangers that accompany CT scans do not apply to MRI scans even though from the outside, the scanners look the same. [Read more in our FAQ section]
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15 September 2009
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Sleep deprivation (SD) affects attention but it is an open question as to whether all subtypes of attention are similarly affected. We investigated the effects of 24 h of total SD on object-selective attention. SD resulted in slower and less accurate picture classification as well as poorer recognition memory for scenes. Attention strongly modulated activation in the Parahippocampal Place Area (PPA). Task-related activation in the fronto-parietal cortex and PPA was reduced in SD, but the relative modulation of PPA activation by attention was preserved... [PDF article]
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22 July 2009
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National Medical Excellence Awards 2009
Professor Michael Chee receives the National Outstanding Clinician Scientist Award for his work on sleep deprivation and healthy aging. This award recognizes individuals with outstanding contributions to clinical and translational research in their specialty.
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11 June 2009
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Study Objectives: We investigated if donepezil, a long-acting orally administered cholinesterase inhibitor, would reduce episodic memory deficits associated with 24 h of sleep deprivation.
Conclusions: Donepezil reduced decline in recognition performance in individuals vulnerable to the effects of sleep deprivation. Additionally, our findings demonstrate the utility of combined fMRI–behavior evaluation in psychopharmacological studies.
Read the full article here.
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30 March 2009
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We investigated the effect of age and health variables known to modulate cognitive aging on several measures of cognitive performance and brain volume in a cohort of healthy, non-demented persons of Chinese descent aged between 55 and 86 years. 248 subjects contributed combined neuropsychological, MR imaging, health and socio-demographic information.
Read full article here.
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20 February 2009: S-LABS Appreciation Tea Party
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CNL recently organised a tea party to thank volunteers for participating in our Singapore Longitudinal Aging Brain Study (S-LABS). In addition to the opportunity to mingle with their peers and the CNL S-LABS team, volunteers were treated to a series of informative talks. Dr Tai Ee Shyong shared on the topic of cholesterol and heart diseases, while principal investigator of S-LABS Dr Michael Chee presented some of the research findings from the project as well as some anti-aging advances.
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Missed the tea party? Now you can download presentation slides of the talks here:
Research Findings from S-LABS | Anti-aging advances | Cholesterol and Heart Diseases
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30 October 2008
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Volunteers Needed!
We are seeking volunteer participation for this current research study:
Attention and Visual Processing in Sleep Deprivation
This study will take place over approximately 2 weeks, and volunteers will undergo 2 magnetic resonance imaging (MRI) scanning sessions, with one session being an overnight sleep deprivation session.
If you are between 21 to 35 of age, with no chronic illnesses and have regular sleeping patterns (at least 6.5 hours of sleep every night), please fill up the sleep questionnaire here to take part in our study.
